The H1N1 flu spread very quickly at the beginning, __________, many people were ill.
A．thereforeB．insteadC．in advanceD．however
A
考查詞義辨析。Therefore 因此，instead 代替，in advance 提前，however
然而，句意：H1N1病毒在開(kāi)始傳播的非常快，因此，許多人病了。所以選A。
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