_____ his knowledge of the mountainous country, John Smith was appointed as our guide.

   A. In spite of      B. On account of

   C. Regardless of    D. Instead of

B. On account of


解析:

on account of(=because of)由于，因?yàn)椤egardless of(=without worrying about)不顧；Regardless of danger, he climbed the tower.

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